• Portland Timbers
  3 - 1
  Tijuana
• Cruz Azul
  1 - 2
  Chicago Fire
• América
  1 - 1 P
  Austin

• New York City
  1 - 2
  Necaxa
• Philadelphia Union
  0 - 2
  Santos Laguna
• Los Angeles FC
  P 1 - 1
  Querétaro
• Seattle Sounders
  1 - 2
  Guadalajara
• San Diego
  3 - 2
  Puebla
• Toluca
  3 - 1
  Dallas
• Monterrey
  2 - 1
  Nashville SC

• Orlando City
  P 2 - 2
  Atlético San Luis
• Inter Miami
  2 - 3
  León
• Tigres UANL
  P 1 - 1
  Vancouver Whitecaps
• Real Salt Lake
  3 - 0
  Juárez
• Charlotte
  0 - 1
  Pachuca
• Minnesota United
  3 - 1
  Atlante
• Cincinnati
  1 - 2
  Atlas

• Columbus Crew
  P 1 - 1
  Pumas UNAM

• América
  3 - 1
  Portland Timbers
• San Diego
  1 - 0
  Tijuana
• Austin
  3 - 0
  Puebla
• Chicago Fire
  3 - 1
  Santos Laguna
• Nashville SC
  4 - 1
  Atlético San Luis

• Philadelphia Union
  3 - 1
  Necaxa
• Cruz Azul
  2 - 1
  New York City
• Seattle Sounders
  3 - 0
  Querétaro
• Toluca
  0 - 1
  Los Angeles FC
• Real Salt Lake
  4 - 0
  Atlante
• Guadalajara
  0 - 1
  Dallas
• Inter Miami
  1 - 2
  Monterrey

• Orlando City
  1 - 2
  León
• Vancouver Whitecaps
  1 - 3
  Juárez
• Tigres UANL
  P 0 - 0
  Minnesota United
• Cincinnati
  2 - 0
  Pumas UNAM

• Columbus Crew
  2 - 1
  Pachuca
• Charlotte
  2 - 0
  Atlas
• Portland Timbers
  5 - 2
  Puebla
• América
  3 - 1
  San Diego
• Austin
  2 - 0
  Tijuana
• Chicago Fire
  2 - 0
  Necaxa
• Cruz Azul
  1 - 0
  Philadelphia Union

• New York City
  2 - 0
  Santos Laguna
• Los Angeles FC
  P 1 - 1
  Guadalajara
• Toluca
  3 - 0
  Seattle Sounders
• Dallas
  2 - 0
  Querétaro
• Nashville SC
  0 - 1
  León

• Monterrey
  1 - 2
  Orlando City
• Inter Miami
  4 - 2
  Atlético San Luis
• Vancouver Whitecaps
  0 - 1
  Atlante
• Tigres UANL
  P 1 - 1
  Real Salt Lake
• Charlotte
  3 - 0
  Pumas UNAM
• Minnesota United
  1 - 2
  Juárez

• Columbus Crew
  3 - 1
  Atlas
• Cincinnati
  3 - 1
  Pachuca